$5,000,000
Business Type: Medical Related Biz / Medical Laboratory; Technology
Medical Related Biz / Medical Laboratory; Technology
This firm develops
life science research tools enabling autonomous, non-invasive, real-time
monitoring of compound bioavailability, biological events, or
viability/metabolic dynamics from any cell using a proprietary synthetic
luciferase technology that does not require external stimulation to function.
The Company’s products are immediately relevant to discovery phase pharmacology
programs as an improved method for accessing the toxicity and metabolic impact
of potential new drug compounds and to in vitro and in vivo basic research and
development activities for interrogating tumor formation, progression, and
recession, cellular health, motility, localization, or transcriptional
activity. Their patent protected synthetic luciferase removes the need for
external stimulation that limits current fluorescent and bioluminescent imaging
approaches. Unlike previous technologies, it can automatically turn on or off
light production to indicate biomarker transcription or changes in
differentiation state, continuously emit harmless visible light to enable
persistent localization and viability tracking, or autonomously adjust signal
intensity to reflect real-time changes in metabolism, toxicity, or any other
desired cellular metric. This solves the problems of uneven excitation and
emission in 3D culture applications, allows the distribution, health, and
propagation of implanted cells to be tracked in real-time in small animal
models, and removes the need to sacrifice precious in vitro samples concurrent
with luciferin exposure. As a simple genetic technology, their synthetic
luciferase can be delivered using the same transfection approaches as older
fluorescent/luminescent genes and expression can be regulated using any
transcriptional or synthetic biology control architecture. This drop-in
replacement capability, combined with improved functionality, enables exciting
new capabilities, and accelerates existing research by producing more data,
reducing costs, and enabling continuous automated tracking without requiring
perturbation at any point throughout the data collection process.
The purchase of this company includes patents, ready-to-ship product
inventory, the bacterial stocks required to make more of the products, all
scientific lab notebooks from R&D operations, and company intelligence
data. The value is based on the "cost to recreate" and projections
based on requests. The products are ready for orders and in demand by some of
the world’s largest biotech companies and most respected researchers. This
company has recently completed the vetting process to have their products
featured in the Thermo Fisher Scientific catalogue. A key element necessary for
growth and marketing of the products is an experienced business development
team. Orders can be worth $1mm each large client within the first 5 years.
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